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del Pozo R, Munoz M, Dumas A, Tapia C, Munoz K, Fuentes F,

In this 52-week trial of 1,698 people with type 2 diabetes whose blood sugar wasn't adequately controlled on Metformin, orforglipron outperformed oral semaglutide on every primary and secondary endpoint, including A1C reduction and weight loss, with improvements visible as early as four weeks

So, going well over what the RDI dictates is non-negotiable, especially when it comes to seniors over 65 who will experience a decline in absorption rates as they age

Many patients find that administering their dose in the evening reduces daytime nausea and digestive discomfort