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Importantly, it has been observed that nuclear translocation occurs at non-toxic doses of paracetamol and at time points before overt toxi-city is observed

Accumulated p53 is stabilized and activated through posttranslational modifications, including methylation, phosphorylation and acetylation, 53 which regulate gene transcription and affect a series of signaling pathways involved in apoptosis, cell cycle arrest, senescence, autophagy, ferroptosis, cellular metabolism and the tumor immune microenvironment (TME) 54,55,56 (Fig

Akkermansia muciniphila mediates negative effects of IFNgamma on glucose metabolism