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These included better blood sugar control, blood pressure, and other markers of metabolic health
These are summarised, together with the studies from which they were reported and the peptides measured, in electronic supplementary material (ESM) section Protein Selection and ESM Tables 1, 2
Together, these pathways highlight how brain health depends on flexible, well-connected neural networks, and why BDNF-related differences may influence how the brain supports cognitive resilience and emotional balance
A post hoc analysis of the phase IIb trial showed that tirzepatide was associated with a reduction in the level of high-sensitivity ICAM-1, CRP, and YKL-40 after 26 weeks of treatment in a dose-dependent manner [83, 103]
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