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Notably, rodents have only the first four GPx isoenzymes (GPx1-GPx4) as the selenoenzymes and the remaining four (GPx4-GPx8) as the cysteine-containing enzymes [1, 8, 9]

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Furthermore, this manuscript aims to situate oxidative stress within a broader geroscience framework by integrating it with the known hallmarks of aging, which collectively contribute to reproductive decline