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S100 proteins in mouse and man: from evolution to function and pathology (including an update of the nomenclature)

Long-term data beyond 12 weeks in humans does not exist from controlled trials

Digestive enzyme supplements are FDA-regulated as dietary supplements under the Dietary Supplement Health and Education Act (DSHEA), rather than medications, except for prescription formulations used for documented pancreatic insufficiency (such as pancrelipase)

In theory, it could also offer rapid absorption into the bloodstream, but this is highly dependent on the formulations ability to overcome the challenges of bioavailability for a large molecule