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RNAi-mediated inhibition of glutathione synthesis impaired survival of multiple colon cancer cell lines, and pharmacological targeting of this metabolic pathway reduced colonization in a primary patient-derived xenograft model

Funding The author(s) declare financial support was received for the research, and/or publication of this article

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Glutathione stabilizes the inner mitochondrial membrane, squelches reactive oxygen species (ROS) generated by mitochondrial respiration, and maintains mitochondrial DNA fidelity to influence mitochondrial function and cell survival