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Potential explanations include differences in the type of patients included, adherence to study treatment, sample size, duration of drug exposure, and GLP1 receptor activation with greater HbA1c reduction with longer-acting human GLP1-based analogs than with some short-acting exendin-4 analogs

A study in the JAMA Network showed that tirzepatide, the active ingredient in Zepbound and Mounjaro, helped overweight or obese adults lose an average of over 20% of their body weight

The effect is largely owing to higher levels of DNA repair endonuclease XPF and DNA excision repair protein ERCC1, which are important components in the NER pathway

The two can stack, and managing that overlap is really the whole game for glp1 no gallbladder patients