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It is an active regulatory period during which the body manages appetite hormones, clears metabolic waste from the brain, and restores insulin sensitivity

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1 Introduction The advent of incretin-based therapies, including glucagon-like peptide-1 receptor agonists (GLP-1RAs) and their combinations, as pharmacological treatments for obesity and type 2 diabetes, has sparked intense debate about their role relative to traditional lifestyle interventions such as exercise and dietary modification