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Emerging evidence suggests GLP-1 receptor agonists are associated with increased gallstone risk, with clinical trials showing gallbladder disorders in approximately 2.6% of patients on semaglutide versus 1.2% on placebo

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While GLP-1 RAs offer promising therapeutic outcomes, clinicians must address potential challenges, including gastrointestinal side effects, contraindications (e.g., pregnancy, severe GI disorders), and risks associated with improper compounding practices (48)(540)

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