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Periodic boundary conditions were used with a cutoff of 10 for non-bonded interactions and the Particle Mesh Ewald method for long-range electrostatics
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Functional GTP cyclohydrolase 1 exists as a homodecamer that consists of two tightly associated dimers that each comprise a pentameric complex of the GTP cyclohydrolase 1 monomers
In the macro-vasculature, OS accelerates atherosclerosis by promoting LDL oxidation, macrophage foam cell formation, and plaque instability via matrix metalloproteinase (MMP) activation (Kowluru and Mishra, 2017), while in diabetic nephropathy, podocyte injury results from NOX4-derived O 2 and mitochondrial ROS-mediated apoptosis (Jha et al., 2024)
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