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Lung ELF GSH is maintained over repeated CS exposures Mice were exposed to CS for 5 h/d for various times to determine when the ELF GSH adaptive response was maximal (Figure 2)
Biomarkers for endothelial function, insulin sensitivity, intracellular signaling, maintaining DNA integrity , inflammation, metabolic flexibility, mitophagy (recycling old and damaged mitochondria) and cellular senescence (also called "zombie cells" as these cells have lost proper function, harm nearby cells and do not die off) are all improved
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It was apparent, however, that agonists diverged both in internalization and recycling capacity, both of which contribute to the net changes to GLP-1R PM residence over time
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