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Excess fumarate, resulting from impaired TCA function, accumulates in the cytoplasm and reacts with thiol groups in crucial cellular proteins, leading to succination and inactivation [81, 82]
Although the results obtained from these preclinical models translate to humans, different mechanisms exist in animals and humans, the investigation of which is a topic for future studies
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Eligible Medicare beneficiaries will now have access to GLP-1 drugs through a $50-a-month copay through the Medicare GLP-1 Bridge, a Centers for Medicare & Medicaid Services initiative launched Wednesday
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