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Dehydration, which can occur with gastrointestinal side effects such as vomiting or diarrhoea, may also contribute to joint discomfort

The Bottom Line GLP-1 medications are no longer just weight-loss drugs. They are anti-inflammatory, metabolically active medications that, for the right patients, can meaningfully improve arthritis and autoimmune disease not by replacing your DMARDs or biologics, but by making them work better and protecting your heart along the way

Subsequently, BioKier demonstrated preclinical proof of concept in the ZDF rat, the industry standard preclinical model of type 2 diabetes, in which an oral formulation of butyrate completely prevented development of diabetes (Figure

Dual and triple agonists Tirzepatide is the first dual GIP/GLP-1 receptor agonist