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Novel studies found that GLP-1RAs such as liraglutide, semaglutide and exendin-4 reduces -synuclein aggregation respectively in MPTP (a mitochondrial complex I inhibitor) and 6-OHDA induced PD mice models as well as rat model of -synucleinopathy
Pyroptosis plays a role in containing infections and promoting immune clearance, but excessive or dysregulated pyroptosis has also been implicated in the pathogenesis of sterile inflammatory and autoimmune diseases
As these weight-loss medications have gained popularity potentially helping obesity rates drop for the first time in a decade theyve also seemed to reduce patients alcohol use, too
The use of lactate for energy has been proposed to occur within the mitochondria where it can be oxidized to pyruvate by mitochondrial LDH which localizes to the inner mitochondrial membrane
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