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By activating GLP-1 receptors in the brain, pancreas, and digestive tract, semaglutide reduces appetite, slows gastric emptying, and improves insulin sensitivity
Participants who delayed their injection by several days still maintained a degree of receptor coverage, reducing the risk of large fluctuations in appetite suppression or metabolic outcomes
Pioglitazone , a thiazolidinedione that improves insulin sensitivity, represents another option, though its use has declined due to concerns about weight gain, fluid retention, potential cardiovascular effects, and a possible increased risk of bladder cancer
