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Those with a BMI between 27 and 30 may qualify if they have at least one weight-related health condition documented in their health history. Weight-Related Health Conditions That May Qualify Weight-related health conditions that can support eligibility include high blood pressure, high cholesterol, heart disease, liver disease, sleep apnea, and polycystic ovary syndrome (PCOS). These conditions indicate that excess weight is already affecting metabolic or cardiovascular health, making medical weight management clinically appropriate

Contraindications and cautions must be carefully evaluated

Pausing semaglutide does not require a dose-down periodyou simply stop the injectionsbut planning your discontinuation in advance allows time to build behavioral strategies for maintaining weight loss through diet and exercise alone during your fertility window

Notably, USP8 is not inhibited by the traditional antimetabolite 5-fluorouracil (5-FU)