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CM13 and CM14 had identical fragment ions at m/z 194 and 288 (Figure 5), indicating further oxidation at the monohydroxylated 5-ethyl side chain to form the ketone form (Scheme 1)
This is followed by the activation of the STAT3 pathway and the induction of M2 polarization, accompanied by upregulation of IL-10 (117)
It should be particularly noted that the IDO-mediated shift of TRP metabolism towards the KP is a key mechanism linking epilepsy with comorbid depression
GLP-1s work by suppressing appetite, slowing gastric emptying, and improving insulin sensitivity in ways that compound over months of consistent use
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