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Across the full treatment period in the STEP 1 trial of FDA-approved semaglutide (Wegovy), this corresponds to an average of roughly 1 to 2 pounds per week, though individual results varied and weight loss was not linear
Notably, 92.8% of the weight lost was attributed to fat mass , far exceeding the 71.8% observed with semaglutide monotherapy
GLP1 receptor agonists act by binding to GLP1 receptors in the gastrointestinal tract, delaying gastric emptying, increasing satiety, and reducing food intake
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