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Understanding PCOS PCOS affects an estimated 1 in 10 women of reproductive age
Front Nephrol
the pentose-phosphate pathway and the synthesis of aromatic amino acids both rely on such enzymes, and these pathways fail during stress (Anjem and Imlay, 2012)
NNMT inhibition reduces one methylation pathway, but it doesn't directly deplete systemic methyl donorsit redirects nicotinamide away from methylation toward NAD+ salvage
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