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Menthol also inhibits the activity of sodium ion channels, which play a crucial role in transmitting chronic pain signals

In ALS models, SOD1 mutations do not markedly alter astrocytic baseline states but lower the threshold for reactivity, which sensitizes astrocytes to oxidative, glutamatergic and inflammatory stress and drives exaggerated reactive responses to otherwise moderate insults 80

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methionine, one of the key ingredients, may aggravate metabolic acidosis and a compromised liver may be unable to properly metabolize the compounds