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The Canadian winter offers natural cold exposure opportunities that complement formal cryotherapy protocols
When cells are exposed to oxidative and/or electrophilic stress, KEAP1 thiol residues are directly modified, which inactivates the ubiquitin E3 ligase activity of KEAP1-CUL3 complex, leading to stabilization of NRF2
No significant differences between control and PXN LOW were observed in aged animals, although a trend was present ( P = 0.07)
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