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Its elimination through tubular secretion without undergoing metabolic changes is a factor that favors its use in combinational therapy.[] In diabetics with hypertension as comorbidity, angiotensin-converting enzyme (ACE) inhibitors or angiotensin-II receptor blockers (ARB) are the most commonly employed antihypertensive drugs.[] ARBs additionally have a favorable influence on insulin's actions and triglyceride (TG) metabolism that are impaired in type 2 diabetes.[] Many compounds in this category affect glimepiride's effectiveness by stimulating or inhibiting CYP2C9, resulting in undesirable hypoglycemia or hyperglycemia
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