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Activation of these receptors could lead to mood stabilization. Recent research out of Israel and published in JAMA Pediatrics in late 2024 supports this theory, as nearly 7,000 adolescents with obesity who initiated a GLP-1 receptor agonist had a 33% lower risk for suicidality compared with controls who underwent behavioral interventions
Some animal studies suggest GLP-1 receptors exist in brain regions involved in stress response, including the hypothalamus and amygdala, raising theoretical possibilities for neuroendocrine modulation
As these medications slow digestion and support long lasting fullness, it is completely normal to experience early symptoms while your body adjusts
The researchers say the drugs accomplish this by repairing tissue damage by reprogramming cells that maintain healthy cartilage
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