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The surge in estrogen and progesterone levels leads to breast enlargement as part of the preparation for breastfeeding
the AP-centric DVC atlas from Ludwig et al
Other reported effects included: Transient fatigue Reduced appetite (therapeutically desirable in the context of weight loss) Mild injection-site reactions Altered skin sensations or cutaneous hyperesthesia (reported in ~7% of participants, mild and non-serious) Serious adverse events were rare and occurred at similar rates in the retatrutide and placebo groups (approximately 4%)
Relapse is driven by Tumor Initiating Cells (TICs), a subset of tumor cells capable of regrowing the tumor and highly resistant to therapy
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