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[2] In other words, the pituitary continues to fire in bursts even when the GHRH signal is sustained, because somatostatin continues to impose its rhythm on top of that signal
It is found mostly in animal products, and absorption from food requires intrinsic factor produced in the stomach
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"The growth hormone/IGF-1 axis is an attractive target for preserving muscle mass in cirrhosis, but the liver's dual role as both a GH effector organ and a metabolic clearance site means that any GH-axis intervention must account for the degree of hepatocellular dysfunction," according to the Endocrine Society's position statement on GH in chronic illness (Endocrine Society Clinical Practice Guideline, 2011)
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