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Subcutaneous administration requires precision equipment
For them, a weight-loss medicine may not solve the main problem
Specifically, leptin promotes macrophage polarization towards a pro-inflammatory M1 phenotype, characterized by the production of cytokines such as IL-6, IL-1, and TNF-, by activating several signaling pathways, including the mTORC2/AKT, MAPK, and PI3K [141, 142]
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