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Quality of evidence is graded as low to moderate by major medical organizations
Deficiency of Trem2 in macrophages worsens lipid accumulation and ferroptosis in TECs via IL-1-dependent CD36 upregulation, thus promoting DKD progression (201)
Applied to the skin in a cream, serum, or balm formulation
Keep it cool, dry, and shielded from direct light before use, refrigerating if holding it longer term
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