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While this study was not a head-to-head clinical trial comparison, it may be relevant that at week 12 of a weekly dosing regimen, some studies suggest that participants treated with semaglutide (Wegovy, Novo Nordisk) had an approximately 6% decrease from baseline in body weight, whereas those treated with tirzepatide (Zepbound, Eli Lilly) had an approximately 8% decrease from baseline in body weight at the same time period, Bays said
However, to maximize the efficacy of these medications, it's crucial to complement them with a healthy diet
Two meta-analyses suggested that pioglitazone reverses or delays the progression of fibrosis, including advanced-stage fibrosis, which is an independent predictor of liver-related adverse events and mortality in MASLD/MASH patients
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