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Pickart and colleagues (Biomed Res Int, 2015) published a comprehensive genome-wide analysis documenting effects on DNA repair pathways (with multiple repair-enzyme genes upregulated, including those involved in nucleotide excision repair and base excision repair), anti-oxidant systems (modulation of superoxide dismutase, catalase, and glutathione-related genes), matrix-remodeling pathways (collagen, elastin, and proteoglycan synthesis enzymes), and inflammatory pathway markers
This does two things: It protects the glutathione from harsh stomach acids
10.1039/c6ra17569d 33 BhuvaneshwariN.ArulmathiM.VenkateshR.BoopathirajaR.Al-LohedanH.BaluR.et al (2024)
[15] In addition, ethical concerns arise regarding the promotion of skin-lightening agents, as these may reinforce colorism and unrealistic beauty standards
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