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Nevertheless, active targeting of functionalized NDDS encounters many obstacles, such as: The problems with this treatment are (i) that it can hurt areas that are not supposed to be treated, (ii) that it can interact with healthy tissues and biological parts (especially proteins) that are not specific to the target, and (iii) that immune cells can get rid of it
10.18632/oncotarget.11459 Oncotarget 244 YaoH.-D.WuQ.ZhangZ.-W.LiS.WangX.-L.LeiX.-G.et al (2013)
However, FOXO4-DRI treatment significantly reduced the expression of these detrimental SASP factors and, critically, restored the proliferation of GC-1 spg cells in the co-culture system, as evidenced by CCK-8 assays and PCNA expression, without inducing apoptosis in the spermatogonia
Definitions Hypertension High blood pressure is above normal
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