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In summary, different GLP-1RAs improve skeletal muscle atrophy through multiple molecular mechanisms, involving multiple pathways such as insulin resistance regulation, inflammation suppression, and mitochondrial function improvement (see Table 1), providing a theoretical basis for the clinical treatment of sarcopenia with GLP-1RAs
Because of the retrospective nature of the study and the use of de-identified data, this study received an exemption waiver for approval and informed consent from the Institutional Review Board (IRB) of Chung Shan Medical University Hospital, identified by the reference number CS1-24047
Mullins CA, Gannaban RB, Khan MS, Shah H, Siddik MAB, Hegde VK, Reddy PH, Shin AC (2020) Neural underpinnings of obesity: the role of oxidative stress and inflammation in the brain
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