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The buildup of ROS resulting in lipid peroxidation and initiation of ferroptosis in chondrocytes aggravates OA
This study evaluated the pharmacokinetics and tolerability of tirzepatide in participants with hepatic impairment (with or without type 2 diabetes) versus healthy participants with normal hepatic function
Importantly, physical performance outcomes such as mobility and functional capacity are generally maintained, indicating that moderate lean mass loss during therapy does not necessarily equate to clinically relevant impairment [19, 26]
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