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Obesity and other metabolic conditions increase the risk of insulin resistance, which can progress to type 2 diabetes
The cultural shift toward recognizing and treating perimenopausedriven by patient advocacy, social media, and high-profile coveragemeans women are presenting earlier, often in their late 30s and early 40s, with irregular cycles, vasomotor symptoms, sleep disruption, and mood changes
Dysregulated IGF signaling seems to be a contributing factor
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