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Weight loss may slow as the body reaches a healthier set point
All animals were fasted overnight and then treated with vehicle (VEH, white bars) or EX-4 (black bars) prior to food intake in order to measure the rate of gastric emptying after a meal
In our model the computed plasma cysteine concentration is 186 M, which is in the middle of this range
Measurement of islet size area Dissected pancreata were fixed in Formalin (Formalin 10% neutral buffered, HT501128, Sigma-Aldrich) for 24 h at room temperature and standardly processed for paraffin embedding (Tissue Tec VIP.6, Sakura Europe) Paraffinized pancreata were exhaustively cross-sectioned into four parallel, equidistant slices per case
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