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The plant-based pesticide rotenone is a prototypical toxin that can mimic clinical and pathological features of PD in an animal model 5

In summary, these studies in regenerating sensory organs suggest that active Wnt/-catenin signaling can increase the extent of mitotic hair cell regeneration (Figure 4), yet the ability of activating Wnt/-catenin signaling alone to renew proliferation and hair cell regeneration observed in the neonatal, immature mammalian cochlea appears limited in the mature, mammalian cochlea

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