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This has led researchers and clinicians to investigate whether newer anti-obesity medications, including GLP-1 receptor agonists like Zepbound (tirzepatide), might offer therapeutic benefits for patients with MASLD beyond their primary indication for weight management and glycemic control
The rate of aging also depends on the amount of IGF-1 and the density of its receptors [177]
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It is worth noting that our participants had a higher baseline BMI (mean 41.5 kg m 2 ) than in the STEP 1 trial (37.9 kg m 2 ), with some studies 24 showing that greater weight loss is observed with a higher baseline BMI, which may explain the greater %WL observed in our trial
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![Structures of (a) GLP-1, (b) GIP and (c) tirzepatide [19, 88, 90]](https://www.researchgate.net/publication/370926483/figure/fig4/AS:11431281185432337@1693619320519/Structures-of-a-GLP-1-b-GIP-and-c-tirzepatide-19-88-90-Amino-acids-are.png)
