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Don't prematurely discontinue if showing gradual improvement
Side Effects Gastrointestinal issues are the primary concern with GLP-1 drugs
Albiglutide is also a once-weekly GLP-1RA consisting of two copies of a 30 amino acid sequence of modified human GLP-1 (replacement of alanine with glycine at position 8) fused with human albumin [22]
Many peptide systems discussed herein have been repeatedly shown to exert robust physiological effects in vivo , often across multiple species, yet lack approved therapeutic analogs or advanced clinical programs despite decades of investigation
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