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It produces the smallest injection volumes, which is convenient but demands extreme precision

The maintenance comparison has not been directly studied, but indirect evidence suggests that patients who switch from tirzepatide to semaglutide for maintenance may experience partial regain due to the loss of the GIP receptor component (Frias et al., NEJM 2021)

Increases in cGMP result in the inhibition of plasma membrane localized L-type Ca 2+ channels resulting in decreasing overall intracellular Ca 2+ which normally serves to activate myosin light chain kinase leading to vasoconstriction

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