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The trial lasted 68 weeks and included 3417 individuals who were randomized to either CagriSema, its individual components or placebo [125]

The studies are correlative, but appear to show that the drugs not only reverse the carcinogenic risks that come with obesity, they may also have additional anti-inflammatory effects that help suppress tumors

The results, which were published in the Lancet on Thursday, are very encouraging for the safety and efficacy of orforglipron in people with type 2 diabetes, says Daniel Drucker, an endocrinologist at the University of Toronto, adding that he is awaiting further clinical trial results of the drug in people with obesity

Yes, doses above 3 mg daily provide minimal additional libido benefits while significantly increasing side effects including severe nausea, hyperpigmentation, and potential cardiovascular stress