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The RT prototypes without the carboxylic acid groups, such as RT-NH 2 and TQG-CN, are fairly hydrophobic and cannot distribute in the nucleus, which is a hallmark of protein binding for fluorescent probes (Fig
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Superimposing a tonic pharmacological brake on top of this feedback system creates competing signals, and it would be unsurprising if intestinal feedback partially normalized emptying over time even while the drug is present
In contrast, clinical trials have yielded mixed results
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