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These disorders encompass a broad spectrum of pathological conditions, show extreme phenotypic variation, and have roughly age-related distribution ( Figures 1 , 2 ) (5)

For diabetes patients, A1c reductions of approximately 1.0-1.5 percentage points are common with GLP-1 receptor agonists, while tirzepatide has shown reductions of up to 2.0-2.3 percentage points in clinical trials

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