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PMID 34463268

Notably, while TMAO is associated with a higher prevalence of prediabetes, it does not appear to significantly influence insulin resistance or longitudinal changes in fasting plasma glucose [24, 61, 66, 67]

However, it is not known whether supplementation with these nutrients improves overall mood or depressive symptoms in those with depression

The latter studies in mice, as well as our recent human study showing that combined EGCG and resveratrol supplementation affects flexibility of postprandial substrate oxidation without changes in systemic lipolysis 19 may suggest that skeletal muscle is a major target tissue for the EGCG-induced metabolic effects