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Any symptoms suggesting thyroid hormone imbalancesuch as new or worsening fatigue, palpitations, heat or cold intolerance, or changes in weight beyond expected GLP-1 effectsshould prompt thyroid function testing and clinical reassessment

When appetite is severely suppressed (especially during the early weeks and after dose increases), prioritize protein over all other macronutrients

Beyond these three papers, review articles referencing the human peptides discovery in the 1970s continue to shape how researchers frame new hypotheses, particularly around why plasma concentration declines with age and what that means for tissue-repair capacity over time

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