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In the most apical region of the epithelium there is an intercellular gap (around 90 ) named zonula occludens or tight junctions, followed by the zonula adherens (gap of 200 ), followed by the macula adherens or desmosomes (gap of ~240 ) ( zonula occludens (ZO) family

The review emphasizes the diverse functions of glutathione, including its role as an antioxidant, regulator of DNA synthesis, and protector of proteins, highlighting its significance in maintaining brain health and combating neurodegeneration These recent scientific studies underscore the importance of glutathione in neurological health and its potential therapeutic implications in various neurological disorders by addressing oxidative stress, neuroinflammation, and neuronal damage 7