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This inhibition compromises the defense systems ability to counteract increased oxidative stress, leading to further damage to retinal cells
Additionally, GSH levels in tumor tissues decreased in the GGCT knockdown group but were restored by NAC, indicating that NAC could elevate the level of GSH by scavenging ROS (Fig
The combination of Reta + anti-PD-1 showed about a 4-fold reduction, but did not significantly outperform either treatment alone
The expression levels of TRINITY_DN25968_c1_g1 (glutamate-cysteine ligase catalytic subunit, GCLC ), TRINITY_DN4779_c0_g3 (glutathione reductase, GR ), TRINITY_DN17069_c0_g1, TRINITY_DN3645_c1_g1, TRINITY_DN47253_c0_g1 (glutathione S-transferase, GST ), TRINITY_DN7687_c0_g1 (5-oxoprolinase, 5-OPase ), and TRINITY_DN20556_c0_g1 (L-ascorbate peroxidase, APX ) were upregulated by 2.995.32-, 2.285.37-, 1.591.94-, 3.453.38-, 1.361.14-, 1.462.41-, 4.196.30-fold (log2), respectively, under Se supplementations, but TRINITY_DN72459_c0_g1 encoding glutathione peroxidase ( GPX ) was downregulated by 1.36- or 1.37-fold
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