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H.ZilinskasB
cAMP directly activates protein kinase A (PKA) and cAMP-regulated guanine nucleotide exchange factor 2 (Epac2), that act in concert to generate downstream signals resulting in increased insulin secretion 8
To ensure that pregnancy has not occurred following a course of clomiphene, adequate evaluation of the patient is necessary before a subsequent clomiphene therapy course is undertaken
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