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507 The brains of individuals with preclinical AD (PCAD) and AD exhibit oxidative damage to a variety of molecules, e.g., accumulation of protein carbonyls (PCs) in regions that are rich in A-peptide-containing SPs, increased lipid peroxidation in AD and PCAD hippocampi and elevated DNA damage

Its protonated epsilon-amino group carries positive charge that affects solubility, chromatographic retention and interaction with polyanionic matrix components, and in a physiological setting the lysine face is implicated in ternary complex formation with serum albumin, which has its own high-affinity N-terminal copper site

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