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According to NICE guidance (NG28), the continuation of GLP-1 receptor agonist therapy in type 2 diabetes should be assessed after six months, with treatment continued only if there is a reduction in HbA1c of at least 11 mmol/mol (1%) and, where applicable, a weight loss of at least 3% of initial body weight

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Plus, in roughly 150 countries, semaglutide was never patented in the first place

In animal and cell models, GLP-1 has been shown to impact the development and/or progression of atherosclerotic plaques