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How This Works Melanotan I is a synthetic analog of -MSH engineered for stability and receptor selectivity
KEGG: Kyoto Encyclopedia of Genes and Genomes
Signs & Symptoms Fatigue, weakness Swelling (edema) in legs, face Decreased urine output (oliguria/anuria) or sometimes polyuria in early CKD Nausea, vomiting, anorexia Shortness of breath (due to fluid overload) Confusion (from uremia) High blood pressure Itchy skin (uremic pruritus) Complications Electrolyte imbalance ( potassium arrhythmias) Metabolic acidosis Anemia ( erythropoietin) Bone disease (due to calcium-phosphate imbalance, vitamin D activation) Cardiovascular disease Management AKI: Treat underlying cause (e.g., fluids for dehydration, relieve obstruction, stop nephrotoxic drugs)
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