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Conditional GPX4 knockout in myeloid lineage cells results in LPO-dependent caspase-11 activation and increase of N-terminal gasdermin D (GSDMD) fragments, which triggers macrophage pyroptotic cell death and release of DAMPs such as high-mobility group box 1, alarmin and pro-IL-1 [118]
Gut lining tissue is highly vascular and responds to BPC-157s signaling faster than musculoskeletal tissue
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Bovendien recyclet het andere belangrijke antioxidanten zoals vitamines C en E
